The Influence of Nifedipine on the Progression of Coronary Artery Disease in Man: The INTACT Study

In recent years, numerous experimental studies have convincingly demonstrated that the simultaneous administration of calcium antagonists attenuates the extent of atherosclerosis induced by a cholesterol-rich diet in rabbits, despite excessive plasma cholesterol levels (up to 2000 mg/dl) [1–4]. These laboratory findings opened a new path for preventive strategies, and might improve the so far insufficient control of coronary risk factors in man.