The toxicokinetics of methyl-ISP in rats.

The toxicokinetics of methyl-ISP was studied in rats. The logarithm of the pesticide concentration in blood versus time curve following intravenous injection was fitted to two-compartment open model. The toxicokinetic parameters are as follows: distribution half life 2 min, elimination half life 3 h, apparent volume of distribution 335.03 ml/100g, total tody clearance 1.28 ml/100g/min. After intravenous injection, the pesticide was distributed mainly in the liver and the lungs, where at subcellular level it was chiefly concentrated in nuclei and mitochondria. 66.43% of the total amount of the pesticide administered was excreted in feces and urine, especially in feces.