Syntheses of D- and L-myo-Inositol 1,2,4,5-Tetrakisphosphate and Stereoselectivity of the I(1,4,5)P3 Receptor Binding.
2010
D- and L-myo-Inositol 1,2,4,5-tetrakisphosphate [D- & L-I(1,2,4,5)P4], which are analogues of D-myo-Inositol 1,4,5-trisphosphate [D-I(1,4,5)P3], a calcium mobilizing second messenger, were synthesized via resolution of the camphanate ester of a myo-inositol derivative, and the binding affinities to I(1,4,5)P3 receptor were measured.
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