Effect of Salvia miltiorrhiza and Bugu capsule on osteoprosis of systemic luus erythromatosus patients.

Objective To investigate the mechanism of salviam miltiorrhiza combined with Bugu capsules in the treatment of osteoporosis or bone loss in systemic lupus erythematosus(SLE) patients after long-term administration of glucocorticoid.Methods Nity SLE cases were divided into randomly.treatment group consisted of 45 cases and treated with glucocorticoid and salviam miltiorrhiza combined with Bugu capsules and control group consisted of 45 cases and treated with glucocorticoid.All patients were evaluated by determination of bone mineral density(BMD)and related biochemical parameters such as serum calcium,serum P,serum ALP and serum parathyroid hormone(PTH)before and after treatment.Results The changes of concentrations of serum calcium,serum P,serum ALP and serum PTH before and treatment in treatment group were no significant(P0.05),while in the control group was significant(P0.01).Osteoporosis or bone loss rate in treatment group was significant lower than that of control group(P0.01).Conclusion Salviam miltiorrhiza combined with Bugu capsules is effective in the treatment of osteoporosis and bone loss in SLE patients.The mechanism may involve the regulation of expression of serum calcium and serum PTH and also improve the bone marrow microenvironment.