Su1660 Pre-Operative Lovenox Does Not Increase Blood Loss During Pancreaticoduodenectomy Compared to Heparin

S A T A b st ra ct s Six patients (5%) with conversion to OPD were included in LPD group based on intent-totreat. Daily opioid consumption of the LPD group was significantly less than that of OPD group from POD 2 through POD 5, and total opioid consumption of LPD group was also significantly less (LPD: 5.3 ± 6.4 mg/kg, OPD: 7.3 ± 9.4 mg/kg, P = 0.007). Multivariate analysis revealed that younger age (, 65 years old) (HR 1.89, 95% CI 1.29 2.79, P = 0.001), no preoperative diabetes mellitus (HR 1.74, 95% CI 1.10 2.80, P = 0.01), PD for chronic pancreatitis (HR 2.87, 95% CI 1.18 7.51, P = 0.02), OPD (HR 2.01, 95% CI 1.26 3.27, P = 0.003) and postoperative major complication (Grade III-V) (HR 2.30, 95% CI 1.36 3.91, P = 0.001) were independently associated with increased opioid consumption after PD (total opioid consumption . 6mg/kg). Conclusion: Patients undergoing TLPD have lless opioid consumption compared to those with the open approach. Younger age, absence of diabetes, chronic pancreatitis indication and major postoperative complications are independent predictors of increased opioid consumption. These findings warrant further evaluation as to the potential clinical impact of reduced pain and less opioid consumption on patient-specific advantages including early recovery and better quality of life after pancreaticoduodenectomy.