Optimisation of methods for driving Chondrogenesis of human and ovine bone marrow–derived stromal cells

This thesis investigated the effects of different molecules and oxygen levels on the quality of engineered cartilage tissues produced using both human and sheep bone marrow–derived stromal cells. As damaged cartilage cannot repair naturally, it is hoped that cell-based repair strategies can delay the need for joint replacement surgery due to osteoarthritis, which affects 1 in 10 Australians.