Morphologic changes in the kidneys in acute kidney failure due to acute pancreatitis

: Light optical and electron-microscopic investigations were carried out on 42 dogs with experimental hypertensive-enzymatic acute pancreatitis. It was revealed that microcirculatory changes appeared already within the first hour of experimental pancreatitis. By the 4th hour of the experiment the changes in basal membrane and podocytes, as well as proliferation of mesangial cells and growth of mesangial matrix were noted. Thus, at the initial stages of acute pancreatitis morphological alterations in the kidneys correspond to the pattern of mesangial proliferative diffuse glomerulitis.