Chemical Synthesis of Meridianins and Related Derivatives

Abstract The meridianins are alkaloids characterized by an indole framework bearing a 2-aminopyrimidine ring at the 3-position. These structures are emerging as valuable pharmacophores following their discovery in the late 1990s and exhibit a wide range of potent biological activities. Modification of derivatives have been a fruitful endeavor and lead to new and/or improved biological activities. Syntheses of these targets have developed from the step-inefficient Bredereck protocol, to a more elegant focus on transition metal catalysis. The disclosed review concerns the synthesis of meridianins and related structures.