Dose Dependent Effect of Olive Leaves Extract on Inflammatory Cyclooxygenase (COX) Levels in High Fat Diet (HFD) Induced Diabetic Animals

Background : Development of diabetes and its complications are associated with persistent inflammatory activity. It has been suggested that COX-mediated pathway involved in this inflammatory process in diabetes. There is a scarcity of the studies on anti-inflammatory effect of olive leaf extract so we have chosen the Olive leaf extract for this study. Materials and methods: Albino Wistar rats were divided into five groups. 1. Control, 2.Control + Olive Leaf extract, 3.High fat diet induced Diabetes, 4.HFD + Olive leaf extract (100mg/kg), 5.HFD + Olive leaf extract (200 mg/kg). Whole blood sample was collected after 9 weeks of experimental period and analysed. Results: Increased COX I expression in platelets & COX II expression in monocytes were observed in HFD diabetic animals when com- pared with control animals. However, olive leaf extract treatment to HFD induced diabetic animals restored the aforementioned parameters to normal level. Conclusion: To the best of our knowledge we have done the first research on anti-inflammatory & hypolipidemic activity of Olive leaf extract and we proved it.