Molecular differentiation of schizoaffective disorder from schizophrenia using BDNF

the so-called ‘Kraepelinian dichotomy’ (dementiapraecox v. manic–depressive illness) has guided both clinicalreasoning and pathophysiological research for a century. Con-sequently, clinicians and researchers often consider schizoaffectivedisorder to be a subtype of schizophrenia or bipolar disorder, eachof which is seen as a discrete nosological entity.