Comparison of sedative recovery time after midazolam versus diazepam administration

Objective: To compare the sedative recovery rate pharmacology of intravenous midazolam vs. diazepam when used for short-term sedation. Data Sources: English-language articles were identified through a search of the MEDLINE and InPharma databases. Bibliographies of retrieved articles were examined for relevant articles. Study Selection: Twenty-eight studies were identified based on a priori inclusion criteria. Eight trials had enough information to combine results for sedative recovery rate. Data Extraction: The difference in mean time to sedative recovery, weighted by sample size, was determined