Trimetazidine in treatment of ischemic heart disease cardiac failure

Objective To observe the cardiac functional effect of TMZ on the patients of chronic heart failure (CHF) with is-chemic heart disease. Methods Choose 94 eases of CHF with isebemie heart disease, divided into two groups randomly: control group (CG) 49 cases received routine treatment ( digitalis, diuretics, vasodilator, ACEI or ARB, β-blocker, ect ) ; group of TMZ(TG)45 eases received TMZ (20 mg/d,3/d) for 6 months on the basis of routine therapy,then observe the conditions of readmis-sion rate(RER)and the improvement of heart fumction.Results ①Follow up for 6 months ,the death of TG was 2 case (4.44%),the death of CG was 5 case (10. 20%) ,and there was no significant in two groups;RER of TG was 8 case (17.78%) ,RER of CG was 18 case (36.73%),and there was great significant in two groups (P<0.05);② 87 cases was survived including CG 44 cases and TG 43 cases come into the result analysis,between which there was no significant in gender,age,risk factors and complication before treatment. The total effective rate of the improvement of heart function of TG was higher than CG (81.40% vs 61.36%,P<0.05).③ HR of the both groups cut down significantly ,and both 6-MT elevate significantly in which TG was higher than CG (521±31 vs 425.94±23, P<0.05). Conclusion The treatment of heart failure by TMZ can depresss the readmission rate, im-prove the heart function and elevate the active endurance. Key words: Trimetazidine; Congestive heart failure; Ischemic heart disease