Metal-free synthesis of 3,3-disubstituted oxindoles via 1,2-alkylarylation of activated alkenes with alcohols
2013
Metal-free synthesis of 3,3-disubstituted oxindoles utilizing N-arylacrylamides and simple alcohols is developed. It provides an efficient method for preparing a series of hydroxyl-containing oxindole derivatives. This reaction is proposed to proceed through oxidative radical cyclization mechanism. The remarkable features of the reaction are metal-free condition and excellent functional group tolerance. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.
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