Functional-biochemical parallels during two-stage devascularization of the liver

After reproduction of acute hepatic failure in dogs by two-state devascularization of the liver (Eck's fistula followed by ligation of the hepatic artery) the dynamics of the blood biochemistry and liver function was studied. The results indicate that disturbances of intermediate metabolism precede the encephalopathy and severe circulatory changes in the body and also accompany them.