Regulation of Bcl-xL: a little bit of this and a little bit of STAT.

The Bcl-2 family of proteins are key regulators of apoptosis. Bcl-xL is an anti-apoptotic protein with a high degree of homology to Bcl-2; however, the signals that regulate Bcl-xL and Bcl-2 appear to be different. Levels of Bcl-xL, but not Bcl-2, are increased in response to various survival signal