Nor-lupane triterpenoid and guaiane sesquiterpenoids from Schefflera venulosa

A novel nor-lupane triterpenoid, 3-oxo-29 alpha-hydroxy-17 beta,20-epoxy-28-norlupane (1), and two new guaiane sesquiterpenoids, schvenols A-B (2-3), has been isolated from leaves of Schefflera venulosa. Structures of the new compounds were elucidated on the basis of their spectroscopic methods, including 1D and 2D NMR techniques. And the structure of 1 was further confirmed by the X-ray diffraction analysis. None of the compounds showed inhibitory effects on NO release in LPS-stimulated RAW 264.7 macrophage cell line. (C) 2015 Published by Elsevier B.V.