Early Prediction of the Development of Microcephaly After Hypoxic-Ischemic Encephalopathy in the Full-Term Newborn

The development of microcephaly after significant hypoxic-ischemic cerebral injury in the fullterm newborn has major prognostic significance. However, the onset of microcephaly in this context may be delayed more than 12 months. Objectives. To determine whether serial head circumference measurements and decreased rate of head growth in asphyxiated full-term newborns during the first few months of life may predict the development of eventual microcephaly. Methodology. Serial head circumference measurements at 4, 8, and 18 months of age were obtained in 54 full-term newborns who had acute, hypoxic-ischemic encephalopathy