Evaluation of combination therapy with M and α receptors antagonist for the treatment of double-J stent related lower urinary tract symptoms

Objective To evaluate the efficacy of combination therapy with M and α receptors antagonist for the treatment of double-J stent related lower urinary tract symptoms. Methods From May 2013 to May 2014, 131 cases, including 71 male and 60 female cases, were accepted the double-J stent indwelling after the ureteral lithotripsy, laparoscopic ureterlithotomy and pyeloureteroplasty.Their data was retrospectively reviewed.The age ranged from 29 to 64 years old, mean (47.4 ± 15.2) years old.They were divided into 4 groups randomly, including group A (control group, n=30), no drugs were taken; group B (tamsulosin group, n=34), 0.2 mg tamsulosin was taken qd; group C (solifenacin group, n=32), 5 mg solifenacin was taken qd; group D (tamsulosin combined with solifenacin group, n=35), 0.2 mg tamsulosin and 5mg solifenacin were taken qd.The IPSS scores, QOL scores and visual analogue pain scale (VAPS) scores were assessed pre-operation, 1 week after operation, and 4 weeks after operation, respectively. Results All patients were followed-up until the end of this study. In each time point, the IPSS scores in group A was 9.01±2.79, 13.18±3.79 and 13.79±3.76, respectively.In group B, the IPSS scores were 7.89±4.29, 12.39±3.90 and 12.21±3.87, respectively. In group C, the IPSS scores were 7.94±4.27, 12.70±4.01 and 11.98±4.69, respectively. In group D, the IPSS scores were 8.21±3.18, 11.97±5.03 and 8.17±3.25, respectively.Significant difference in total IPSS scores and obstruction symptom scores were shown between pre- and post-operation (P 0.05). Conclusion M and α receptors antagonist combination therapy can significantly improve lower urinary tract symptom due to indwelling double J stents. Key words: Solifenacin; Tamsulosin; Double J stent; Lower urinary tract symptom