DNA hydroxymethylation increases the susceptibility of reactivation of methylated P16 alleles in cancer cells

Paiyun Li,Ying Gan,Sisi Qin,Xiao Han,Chenghua Cui,Zhaojun Liu,Jing Zhou,Liankun Gu,Zheming Lu,Baozhen Zhang,Dajun Deng

DNA hydroxymethylation increases the susceptibility of reactivation of methylated P16 alleles in cancer cells

2019

Paiyun Li
Ying Gan
Sisi Qin
Xiao Han
Chenghua Cui
Zhaojun Liu
Jing Zhou
Liankun Gu
Zheming Lu
Baozhen Zhang
Dajun Deng

ABSTRACTIt is well established that 5-methylcytosine (5mC) in genomic DNA of mammalian cells can be oxidized into 5-hydroxymethylcytosine (5hmC) and other derivates by DNA dioxygenase TETs. While c...

Keywords:

DNA Hydroxymethylation
Cancer cell
Biology
DNA
Genetics
Allele
Dioxygenase
Molecular biology
genomic DNA
Methylation
CpG site

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