Beneficial Effects of H290/51, a New Lipid Peroxidation Inhibitor, on Functional Recovery After Ischemia and Reperfusion in Isolated Cold-Arrested Rat Hearts

Lipid peroxidation is one of the major mechanisms involved in free radical-mediated postischemic myocardial injury. In the present study, a newly synthetized lipid peroxidation inhibitor H290/51 [cis-7metyl-9-methoxy-5,5a,b, 10b-tetrahydroindeno(2,1-6 indole)] was evaluated for its effects on myocardial functional recovery during reperfusion after 30-min global ischemia in isolated cold-arrested rat hearts. Administration of 200 and 800 nM H290/51 at initiation of global ischemia markedly improved the functional recovery, whereas 50 nM H290/51 had no significant effects. The percent recovery of cardiac output (CO), left ventricular developed pressure (LVDP), and LVdP/dt max at the end of the 30-min reperfusion period in the working mode was much higher in the groups receiving 200 and 800 nM H290/51 than that in vehicle group (CO 73±5 and 60±5 vs. 23±7%; LVDP 79±5 and 73±8 vs. 43±10%; LV dP/dt max 78±5 and 69±4 vs. 45±10%). The indenoindole compound H290/51 reduced ischemic-reperfusion-induced cardiac dysfunction