The Changes in Endothelium-dependent Vasodilatation in the Different Developmental Phasesof Type 2 Diabetes

Objective To study the changes in endothelium-dependent vasodilatation in the differentdevelopmental phasesof type 2 diabetes. Methods Endothelium-dependent flow-mediated dilation (EDF) test was carried out in thirty three normal subjects and 96 patients(30 IGT, 30 type 2 diabetes without vascular complications, and 36 type 2 diabetes with vascular complications). ResultsCompared with controls(13.08%±4.90%), EDFinthe IGT group was lower(10.46%±4.54%), with the diabetes had even lower EDF(6.25%±2.95%). However, the diabetes with vascular complications was shown to exhibit a lowest EDF(5.17%±2.11%, P0.01). Conclusion The fact that impairment with EDF was present in the early phases of type 2 diabeteswithout clinic evidence of vascularcomplications suggests brachial artery EDF can be used to detect the vascular complications in diabetes.