HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects

Maria J. Buzon,Marta Massanella,Josep M. Llibre,Anna Esteve,Viktor Dahl,Maria C. Puertas,Josep M. Gatell,Pere Domingo,Roger Paredes,Mark E. Sharkey,Sarah Palmer,Mario Stevenson,Bonaventura Clotet,Julià Blanco,Javier Martinez-Picado

HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects

2010

Maria J. Buzon
Marta Massanella
Josep M. Llibre
Anna Esteve
Viktor Dahl
Maria C. Puertas
Josep M. Gatell
Pere Domingo
Roger Paredes
Mark E. Sharkey
Sarah Palmer
Mario Stevenson
Bonaventura Clotet
Julià Blanco
Javier Martinez-Picado

Despite highly active antiretroviral therapy, active replication persists and drives immune activation in some individuals with HIV. This activation is higher if therapy is intensified by additional antiretroviral drugs (pages 373–374).

Keywords:

Raltegravir
Virology
Immunology
Viral replication
Immune system
ANTIRETROVIRAL AGENTS
Medicine
immune activation
human immunodeficiency virus
antiretroviral therapy

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