The effect of hydrocortisone on a neurogenic pain syndrome in rats

: The effect of sex hormones on lipid peroxidation (LPO) in the wall of the aorta of male rats was studied in vivo and in vitro. Female sex hormones (17 beta-estradiol and progesterone) inhibited LPO in the aorta: 17 beta-estradiol caused a maximum antioxidant effect at the beginning of its action, progester one during prolonged action. Testosterone had a marked prooxidant effect, activating lipid LPO in the aorta both in vivo and in vitro whatever its concentration and duration of incubation.