Herbisidlere maruz kalma ile koroner arter ektazisi arasındaki ilişki

Suleyman Demirel Universitesi TIP FAKULTESI DERGISI: 2007 Eylul; 14(3) Herbisidlere maruz kalma ile koroner arter ektazisi arasindaki iliski Mehmet Ozaydin*, Halil Kahraman*, Ercan Varol**, Suleyman M. Aslan*, Abdullah Dogan*, Ahmet Altinbas* *Suleyman Demirel Universitesi, Kardiyoloji AD, Isparta, **Isparta Devlet Hastanesi, Isparta Ozet Anjiyografik olarak, epikardiyal koroner arterlerde obstruktif lezyon olmaksizin normal luminal captan 1.5-2 kat arasinda genisleme koroner ektazi, 2 kattan fazla genisleme ise koroner anevrizma olarak tanimlanmaktadir. Ciftcilerin yaygin olarak kullandiklari herbisidlere uzun sure maruz kalinmasi asetilkolin konsantrasyonunu artirarak nitrik oksit uzerinden vaskuler duz kaslarda relaksasyona neden olmaktadir. Fakat kronik relaksasyonun koroner arter ektazisine neden olup olmadigi bilinmemektedir. Calismamizin amaci, izole koroner arter ektazisi olan olgularda kontrol grubuna gore herbiside maruz kalma sikligini arastirmakti. Anahtar kelimeler: Koroner arter ektazisi, herbisid Abstract The relationship between exposure to the herbicides and coronary artery ectasia The dilatation of the epicardial coronary arteries 1.5-2 times that of normal adjacent segment is called coronary ectasia and >2 times that of normal adjacent segment is called coronary aneurysm. Longterm exposure to the herbicides, which are frequently used by farmers, cause relaxation in the vascular smooth muscles via nitric oxide by increasing acetilcholin concentrations. However, it is unknown whether chronic exposure to these substances causes coronary ectasia. Therefore, the aim of the present study was to compare the rate of exposure to these herbicides in patients with coronary ectasia and control group. Key words: Coronary artery ectasia, herbicide