Postprandial serum gastrin concentrations in normal foals

Summary Postprandial gastrin concentrations were assayed in serum samples from a group of six foals at one day, one week, one month and three months of age. Before sampling, each foal was prevented from feeding for 2 h and was then allowed to suck for 15 mins. Blood samples were taken at the start of the meal and at 30 min intervals for the next 3 h. Feeding increased serum gastrin concentrations at one day, one week and one month, with the greatest increases detected at one day. Mean pre-feeding gastrin concentrations were 25.2 ± 2.3 pg/ml at one day, 22.8 ± 3.9 pg/ml at one week, 15.2 ± 2.3 pg/ml at one month and 15.6 ± 7.5 pg/ml at three months. Highest mean post prandial concentrations were at 60 mins on Day one (47.4 ± 15.2 pg/ml) and at 30 mins for the one week (44.4 ± 14.2 pg/ml) and one month (25.2 ± 4.1 pg/ml) old foals. There was no apparent post prandial increase in serum gastrin concentrations in foals at three months of age. Precise reasons for changes in postprandial serum gastrin concentrations remain unknown. Factors that could be important include maturation of G cell function, alterations in gastrin metabolism and excretion, and changes in gastrointestinal motility with increasing age.