Synthesis, spectral characterization and biological activity of Zn(II) complex with 2′-[1-(2-hydroxyphenyl)ethylidene]benzenesulfanohydrazide

Zinc(II) complex with 2 0 -(1-(2-hydroxyphenyl) ethylidene) benzenesulfanohydrazide, was synthesized, and structurally characterized by elemental analysis CHN, TGA, UV, FT-IR, 1 H NMR and 13 C NMR spectroscopy. Its preventive effect on ulcer activity induced by absolute eth- anol in Sprague-Dawley rats was studied in vivo. Gastric ulcers were induced in rats by administrat- ing absolute ethanol. Twenty four Spragu-Dawley rats (12 males and 12 females) were assigned equally into the following 4 groups (n = 6): negative control; positive control; low dose, which received low oral doses of the compound; and high dose, which received high oral doses of the com- pounds . These animals were subjected to overnight fasting (food but not water) prior to dosing. Gastric wall mucus, ulcer areas and histology of gastric walls were assessed in addition gastric homogenate was determined for superoxide dismutase (SOD), glutathione (GSH) and malondialde- hyde (MDA). Pre-treatment of rats with compound significantly prevented ethanol-induced gastric wall depletion and restored non-sulfhydryl (NP-SH) content in glandular stomachs. The Zinc(II) complex also exhibits high levels of SOD, and GSH enzymes as well as a reduced amount of lipid