Combined effects of quercetin and curcumin on anti-inflammatory and antimicrobial parameters in vitro.

Abstract In this in-vitro study, combinatory anti-inflammatory interactions between Quercetin (Q) and Curcumin (C) along with their combined antimicrobial activity against MRSA were studied. Anti-inflammatory markers of (i) COX-2 expression, (ii) NFκβ activation and (iii) NO levels were investigated. Antimicrobial synergy was tested by checkerboard assay. We found that, treatment with the “low-concentration combination group” (QC), where Q and C were combined, resulted in significant downregulation of COX-2 expression ( P P P P