Blood lipids in offsprings of patients with ischemic heart disease

AIM: To elucidate correlations between characteristics of lipid metabolism in patients with ischemic heart disease and their offsprings. MATERIAL: Patients with overt ischemic heart disease (probands, n=24, mean age 53-/+1.9 years), their first (n=25, mean age 25.7-/+1.8 years) and second generation (n=20, mean age 13.5-/+1.3 years) offsprings. METHODS: The following parameters were studied: levels of lipids, lipoproteins, native and modified serum apolipoproteins, composition of phospholipids and fatty acids in blood erythrocytes, content of intracellular cholesterol in human aortic intima smooth muscle cells in vitro. RESULTS AND CONCLUSION: Members of a family had similar characteristics of lipid metabolism. According to levels of lipids, characteristics of composition of phospholipids and fatty acids in erythrocytes, presence of atherogenic factors in blood serum three variants of family traits of disturbances of lipid metabolism were distinguished.