Novel drug chiral resolution nano chromatographic column and preparation method thereof

The invention belongs to the technical field of analyzing and discloses a novel drug chiral resolution nano chromatographic column and a preparation method thereof. The novel drug chiral resolution nano chromatographic column comprises a modified nano silicon dioxide filler which is filled in a chromatographic column body, wherein the modified nano silicon dioxide filler is prepared by the following steps: modifying nano silicon dioxide by using a silylating reagent, and reacting the modified nano silicon dioxide with modified (1R,3S) camphanic acid so as to obtain the modified nano silicon dioxide filler; then putting the modified nano silicon dioxide filler into the chromatographic column body by using a chromatographic filling pump. The novel drug chiral resolution nano chromatographic column disclosed by the invention is good in stability and high in separation efficiency, is used for high performance liquid chromatography, and can be used for performing fast and high-efficiency resolution on chiral drugs, so that the resolution detection on the chiral drugs is realized.