Acute phase response in Wistar rats after controlled hemorrhage
2011
After injury the acute-phase response of the organism activates mechanisms
which imply the release of cytokines, stress hormones, and mediators of pain
and inflammation. The main function of the acutephase response is to hinder
further damage of the injured tissue by activating reparative processes. The
increase in the concentration of acute phase proteins and the concurrent
decrease in albumins and prealbumins indicate that there is a strong link
between the liver and the traumatized site. Considering bleeding to be a
major injury it can be supposed that it can result in changes in acute phase
proteins concentrations despite the fact that it is not directly related to
inflammatory reactions. In order to confirm this presumption the
concentration changes in negative and positive acute phase proteins in Wistar
rats' blood plasma were measured during a 10 day period after controlled
bleeding. The result of the therapeutic effects of transfusion on acute phase
proteins was estimated in a group of rats in the so called "hospital stage"
at which the blood loss was recovered by citrate blood transfusions. At the
end of the 10th day the rats were monitored for an additional 10 day period.
The obtained results confirm that bleeding is an impressive trauma and the
acute phase response results in a significant change in acute phase proteins.
These changes arise quickly, the highest concentrations were achieved within
the first 24 to 72h and thereon they slowly declined.
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