F-labeled substituted quinazoline compounds and methods of tumor imaging applications pet

The present invention provides a novel quinazoline substituted 18F labeled compound, wherein: one end having the structure 18F alkoxy; and the other end having a 6,7-substituted quinazoline structure, the substituents R1 located quinazoline the parent 4, 2-, 3-, 4-, 18F-substituted alkoxy group; the substituent R2 located on six parent quinazoline, methoxy ethoxy, methoxy, propoxy morpholine group. The structural formula A. Experiments show that the compounds have excellent biological activity, good serum stability, low uptake in the liver and other tissues, have a higher enrichment and slower clearance rates in tumors, and while such compounds prior to labeling body ease of synthesis, high mark rate, various advantages, such compounds show has become a tumor PET imaging has great potential.