The role of autophagy in insulin resistance

Insulin resistance(IR) is one of the main causes of type 2 diabetes mellitus (T2DM),patients with T2DM almost experience long-term IR before they were diagnosised.Recent studies show that insulin signaling pathway,mitochondrial dysfunction,oxidative stress,endoplasmic reticulum stress and free fatty acids which participate in IR are all correlated with autophagy.But it is still uncertain that the mechanism and effect of autophagy on IR. Key words: Autophagy; lnsulin resistance; Type 2 diabetes mellitus