An Experimental Study of the Antipyretic Effect of Xiaoertuiretie Antifebrile Straps for Children

Objective:To evaluate the antipyretic effect of Xiaoertuiretie in an experimental study. Methods:An animal model of fever was set up in rabbits according to the methods described in practical animal models of syndromes defined by the traditional chinese medicine. The rabbits were randomly divided into 5 groups, receiving large, medium, and small dosages of Xiaoertuiretie , 0.9% sodium chloride injection and compound aspirin (APC), respectively. Dynamic changes in body temperature of the animals were recorded in different periods after the treatment and a temperature reaction curve was plotted. Results: Xiaoertuiretie began to exert its antipyretic effect 90 min after medication and it was in this way similar to APC. The antipyretic effect of Xiaoertuiretie lasted 360 min while that of APC, 300 min( P 0.05). Conclusion: Xiaoertuiretie was shown to have a striking antipyretic effect on the fever induced by inactivated E.Coli in rabbits. Its antipyretic effect was comparable with that of APC and lasted even longer than that of APC.