Hypergranulation during dry socket healing following concentrated growth factor therapy

Abstract A 33-year-old male suffered from a dry socket following extraction of a lower molar tooth which was treated with a cocktail of autologous concentrated growth factor (CGF). The healing socket responded with hypergranulation phenomena that is unusual in dry socket condition. Local healing potential of poorly vascularized dry socket usually demonstrate a dragging recovery period instead of a quick granulation tissue response. The reddish sprout of granulation tissue in this case extended over the upper edge of the wound. The over-healing tissue was observed closely and confirmed to be a benign condition. The excess tissue was trimmed to avoid trauma from occlusion following which the socket healed within two weeks. This case suggests the likelihood of a potent cocktail of growth factors could potentiate angiogenesis and vascularization in the dry socket, providing the opportunity towards hypergranulation state. An over-healing state may point towards a remote possibility of malignancy development that need to be alerted. The use of autologous growth factors for dry socket and wound healing would continue in this era of regenerative medicine therapy. However, the inability to precisely control its molecular potential to the required individual need remain a challenge in surgical practice.