The Tyrol Study SCLC Project: Retrospective Analysis of Clinical Features and Therapeutic Outcome in 484 Small Cell Lung Cancer Patients Diagnosed 1991 – 2011

ABSTRACT Introduction Consecutive SCLC cases treated in Innsbruck/Natters Comprehensive Cancer Center were analysed in order to achieve results in the routine setting and to depict cohorts with long term survival. Methods All patients with SCLC were documented with respect to disease and therapy features aiming at describing this disease and treatments applied in most possible detail. Results Of 484 patients, 326 (67%) were male. Extensive stage at diagnosis in 269/483 informative cases (56%), (former) smokers, 316/323 (98%); unfavorable ECOG PS (≥2), 100/303 (33%). Symptoms at initial diagnosis: hemoptysis 44/293 (15%), cough 165/299 (55%); dyspnoea 153/302 (51%); tumor pain 135/305 (44%); neurologic symptoms (incl. paraneoplasia) 69/314 (22%); hyponatremia (≤130 mmol/l)/SIADH 47/339 (14%); prior/present other malignancy 86/436 (20%). 27 patients (6%) did not receive any treatment. 26 limited disease patients were radically operated, with excellent outcome (median OS, 91 months). In the 406 evaluable patients with palliative therapy, overall response (ORR) was 56% (CR 18%, PR 39%, PD 31%, interruption 5%, death under therapy 8%); however, best response (at any time during treatment) was 78%. ORR was dramatically inferior in patients with advanced stage, unfavorable PS, and elevated LDH (p  Conclusion We are working on the establishment of diagnostic and therapeutic algorithms for an optimized management in this unfavourable disease. Disclosure All authors have declared no conflicts of interest.