Morphofunctional characteristic of gastric adipocytes in patients with type 2 diabetes mellitus

Aim. To measure gastrointestinal hormones in plasma, evaluate morphofunctional state of G- and beta-cells in patients with gastric pathology and concomitanttype 2 diabetes mellitus (DM2). Materials and methods. A total of 84 patients with gastric ulcer (GU) and chronic gastritis (CG) were available for observation including 46 with DM2.Semi-quantitative evaluation of stomach infection by H.pylori. was performed by a histological method. Stained G- and beta-cells were counted under 400xmagnification in 10 fields of vision for each medicinal preparation used in the study. Chromogranin A, somatostatin, and gastrin were detected by immunohistochemicalmethods, gastrin-17 and somatostatin-14 by the respective immunoassays. Control group comprised 10 practically healthy volunteers. Results. Patients with combined GU (or CG) and DM2 pathology had smaller density of G- and beta-cells, lower plasma gastrin and somatostatin levelsthan those without DM2 (p Conclusion. Metabolic disorders, local trophic disturbances, accelerated extrusion of erythrocytes, H.pylori colonization, and impaired regenerationin patients with DM2 cause atrophic changes in gastric mucosa, alter the number and ratio of G- and beta-cells.