ОБОСНОВАНИЕ ПРИМЕНЕНИЯ КЛАРИТРОМИЦИНА ДЛЯ ЛЕЧЕНИЯ ПСОРИАЗА

Claritromycin influence on the keratinocytes proliferation and differentiation and lymphocytes proliferation and clasters of differentiation expression in vitro was investigated. It was established that claritro� mycin in dose 2 mkg/ml inhibited psoriatic keratinocytes proliferation and increased its differentiation degree in culture. Claritromycin influence was mediated by CD4 + lymphocytes. Furthermore, claritromycin in vitro de� creased the number of СD25 + lymphocytes and spontaneous and PHAinduced lymphocytes proliferation for psoriatic patients. These data allow to include claritromycin in the treatment regimen of psoriasis. (Med. Immu� nol., 2005, vol.7, № 4, pp 405�410)