2P-208 : Photochemical cellular internalization to overcome cancer drug resistance using polymeric micelle

Resistance of cancerous cells is the foremost threat in the traditional cancer chemotherapy. Cancerous cells express multiple drug resistance (MDR) by developing resistance to various anticancer agents, resulting from various factors such as individual genetic factors or cellular molecular targets. Drug-loaded biodegradable nanoparticle has developed to enhance cellular internalization, but it is not effective. Therefore, photochemical internalization (PCI) was adopted for chemo-drug to effectively permeate cellular membrane. Photochemical inter-nalizable micelle (PCIM) was developed, based on non-ionic triblock copolymer conjugated with photosensitizers. The doxorubicin- loaded PCIM disrupted through lipid peroxidation by reactive oxygen species formed by photosensitizers under laser irradiation. Further, we have expected for this study to represent a potential platform for drug resistant cancer cell therapy.