Pathological alterations in the spleen induced by cadmium and chlorpyriphos in male Wistar rats

The main objective of the study was to know the pathological alterations of the spleen due to toxic effects of cadmium and chlorpyrifos. Present work was carried out for 28 days in rats. 1: Control. 2: CdCl2 @ 22.5mg/ kg b.wt / oral. 3: CPF @ 25 mg/ kg b.wt /per oral. 4: CdCl2@22.5 mg + CPF @ 25 mg/ kg b.wt /per oral. Sections of spleen of group 2 rats, on 15th day of experiment revealed mild to moderate vacuolation, thick trabeculi; on 29th day shrunken red pulp, hypoplasia of white pulp and dilated splenic vessel with thickening of the wall. Spleen sections of group 3 rats on 15th day showed hypoplasia of white pulp and thick trabeculi with haemorrhages and extension of trabeculi with focal areas of hypercellularity. On 29th day in addition to the above changes, shrunken red pulp and vacuolation were observed. Group 4 rats spleen on 15th and 29th day of the experiment showed similar lesions as seen in groups 2 and 3 but the lesions were moderate. The pathological changes in spleen in combined group were severe than individual groups due to synergistic action of the combined pollutants.