Synthesis of 1,2‐Benzothiazines by a Rhodium‐Catalyzed Domino C—H Activation/Cyclization/Elimination Process from S‐Aryl Sulfoximines and Pyridotriazoles.
2016
A method for the synthesis of a large number of 1,2-benzothiazines bearing pyridyl as well as carbonyl groups is developed from rhodium-catalyzed carbene insertions into aromatic C–H bonds of S-aryl sulfoximines using pyridotriazoles by denitrogenative cyclization followed by the elimination of alcohols. The present method involves the N–H/C–H activation of simple alkyl aryl sulfoximines and has the advantages of a broad substrate scope, high functional group tolerance, and good regioselectivity.
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