880. Towards a Gene Therapy Treatment for Peripheral Vascular Disease – High Level of Expression of Angiogenic Genes in Rat Limb Muscle Following Intravenous Delivery of Plasmid DNAs

Despite a lack of success in clinical trials, gene therapy remains a highly promising therapeutic approach for the treatment of peripheral vascular disease. The precise reasons for the poor success rates in the clinical studies remain unclear but it has been postulated that low levels of angiogenic gene transfer and expression may be a primary contributing factor.