The role of brain-derived neurotrophic factor in neural circuit development and function

Abstract Brain-derived neurotrophic factor (BDNF) is a key molecule involved in various aspects of neuronal circuit development and function. In this chapter, we will first discuss the complex transcriptional and translational regulation of BDNF, its secretion, and receptor-mediated actions at pre- and postsynaptic sites. Next, we will cover how those functions affect neural circuit development and maturation. Finally, we will highlight a selection of important findings regarding the role of BDNF in the context of specific neural circuits affecting normal behavior and disease, though this section is by no means an exhaustive treatment of the findings regarding BDNF.