Marine natural products as inhibitors of cystathionine beta-synthase activity

Abstract A library consisting of characterized marine natural products as well as synthetic derivatives was screened for compounds capable of inhibiting the production of hydrogen sulfide (H 2 S) by cystathionine beta-synthase (CBS). Eight hits were validated and shown to inhibit CBS activity with IC 50 values ranging from 83 to 187 μM. The majority of hits came from a series of synthetic polyandrocarpamine derivatives. In addition, a modified fluorogenic probe for H 2 S detection with improved solubility in aqueous solutions is reported.