Su1626 Diagnosis and Pathophysiological Evaluation of Functional Dyspepsia by a Novel Drinking-Ultrasonography Test

intragastric pressure was measured with a transducer until patients expressed gastric discomfort. Time to the threshold of gastric discomfort was measured and analyzed. After the first examination, rabeprazole (10 mg/day: for 4 NERD patients, 2 weeks), mosapride (15 mg/ day: for 5 FD patients (PDS 4, EPS 1), 2 weeks) or itopride (150 mg/day: for 3 FD patients (PDS 3), 2 weeks) were administered and additional insufflation tests were performed. Results: (1) Time to threshold of gastric discomfort: The time to reach threshold pressure was significantly shorter in the FD group and in the NERD group than in the healthy control group (P<0.05). Symptoms at the threshold were abdominal distention or stomachache. (2) The effect of medication on the time to threshold: The time to threshold with rabeprazole, mosapride or itopride was significantly longer than without medication. Conclusions: The results of this study suggest that the time to threshold of gastric discomfort may be useful for diagnosing FD. This method may also be useful for evaluating the efficacy of medication on the pathophysiology of FD.