Hyaluronidases for treating complications by hyaluronic acid dermal fillers: evaluation of the effects on cell cultures and human skin

Background Hyaluronidases are commonly employed in aesthetic medicine to reverse the effects of the injected hyaluronic acid filler, eliminating nodules, correcting the injection of excessive quantities of filler, or reducing the odds of ischemic complications, although toxicity studies and clear guidelines are lacking in the literature. The objective of this study was to evaluate effects of hyaluronidases on skin and soft tissue viability.