Isolation, characterization, and possible anti-Alzheimer's disease activities of bisabolane-type sesquiterpenoid derivatives and phenolics from the rhizomes of Curcuma longa.

One new bisabolane-type sesquiterpenoid ( 1 ), together with four known bisabolane-type sesquiterpenoid derivatives and seven phenolics, was isolated from the rhizomes of Curcuma longa . Their structures were elucidated by extensive spectroscopic (IR, HRESIMS, and NMR) data analysis. The possible anti-Alzheimer's disease ( AD ) activities of 1 - 12 were also evaluated using Caenorhabditis elegans AD pathological model, and compound 2 had the highest possible anti-AD activity.