Comparison of intracellular responses between HBV genotype A and C infection in human hepatocyte chimeric mice

Ken Tsushima,Masataka Tsuge,Nobuhiko Hiraga,Takuro Uchida,Eisuke Murakami,Grace Naswa Makokha,Mio Kurihara,Motonobu Nomura,Yuichi Hiyama,Hatsue Fujino,Atsushi Ono,Takashi Nakahara,Masami Yamauchi,Hiromi Abe-Chayama,Tomokazu Kawaoka,Daiki Miki,Michio Imamura,Hiroshi Aikata,Clair Nelson Hayes,Kazuaki Chayama

Comparison of intracellular responses between HBV genotype A and C infection in human hepatocyte chimeric mice

2019

Background and aims The clinical course and responsiveness to antiviral treatments differs among hepatitis B virus (HBV) genotypes. However, the cause of these differences is unclear. In the present study, we compared mRNA expression profiles in human hepatocyte chimeric mice infected with HBV genotypes A and C.

Keywords:

General surgery
Gene expression
Hepatocyte
Immune system
Virology
Intracellular
Genotype
Hepatitis B virus
Messenger RNA
Medicine
Diabetes mellitus
Cytokine
Gene
Signal transduction
Chemokine

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