Nucleotide sequence analysis of the NSP4 gene from group A rotaviruses isolated in Nizhni Novgorod

The complete nucleotide sequences of the NSP4 gene from Russian isolates of Group A rotaviruses with different G[P] types obtained in Nizhni Novgorod have been first ascertained. They belong to their affiliation to three NSP4 (A, B, and C) of the 5 known genotypes. Eleven strains had NSP4 genotype. Phylogenetic analysis based on the complete nucleotide sequences of the NSP4 gene revealed the sequence homology of G1P[8] viruses with the strains circulating in Scandinavia and that of the G3 type viruses with the strains from South-Eastern Asia. The rotavirus strains G1, G3, G4, and P[8] demonstrated the homology with porcine rotavirus strains, while the strains G3P[6], G3P[9], and G2P[4] did the homology with bovine rotavirus strains. There was an unusual strain of human rotaviruses G3P[9] genetically related to feline rotaviruses.