Bioactive compounds from Selaginella involven Spring that protect PC-12 cells

Abstract Two new compounds named as 3 β ,12,16-trihydroxy-6,8,11,13-abietatrien ( 1 ), (8R,8′S)-4,4′,8-trihydroxyl-3,3′-dimethoxyl-9′-lignanolide ( 2 ) and a new natural product 4,4′-dihydroxyl-3,3′,5,5′-dimethoxyldiphenyl diketone ( 3 ) were isolated from the whole herbs of Selaginella involven Spring. The structures were elucidated by spectroscopic analyses including UV, IR, 1D, 2D NMR and MS methods. Additionally, these three compound s exhibited potent protective effect against the injury of PC-12 cells induced by hypoxia/reoxygenation.