Neutrophil to lymphocyte ratio as a prognostic marker in metastatic gallbladder cancer

Abstract Background Neutrophil-to-lymphocyte ratio (NLR) has been used as an inflammation based prognostic marker for various malignancies. This study evaluated the association between NLR and overall survival (OS) in patients with metastatic gallbladder cancer (GBC) Methods An optimal cut off point for NLR was identified by plotting spline-based hazard ratio curves to identify a threshold effect and patients were divided into two groups, ≥5 or Results Of the 231 patients included, 138 (60%) had NLR Conclusion The current study demonstrates that NLR ≥5 is an independent predictor of poor prognosis in patients with metastatic GBC.